The DP subregion of the human major histocompatibility complex contains two closely linked gene pairs, DP alpha, DP beta and SX alpha, SX beta. The exon-intron organization and the complete DNA sequence of the SX alpha gene are reported here. There are several mutations within the SX alpha gene which strongly suggest that it is a pseudogene. These include two frameshift mutations, one in the alpha 1 domain and the other in the cytoplasmic domain. A 5' splice site mutation at the end of the alpha 1 exon also exists. DNA sequence homology between DP alpha and SX alpha suggests that these genes arose through a gene duplication event.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
The DP subregion of the human major histocompatibility complex contains two closely linked gene pairs, DP alpha, DP beta and SX alpha, SX beta. The exon-intron organization and the complete DNA sequence of the SX alpha gene are reported here. There are several mutations within the SX alpha gene which strongly suggest that it is a pseudogene. These include two frameshift mutations, one in the alpha 1 domain and the other in the cytoplasmic domain. A 5' splice site mutation at the end of the alpha 1 exon also exists. DNA sequence homology between DP alpha and SX alpha suggests that these genes arose through a gene duplication event.
|
| skos:exactMatch | |
| uniprot:name |
Mol. Cell. Biol.
|
| uniprot:author |
Auffray C.,
Boss J.M.,
Mengler R.,
Okada K.,
Strominger J.L.
|
| uniprot:date |
1985
|
| uniprot:pages |
2677-2683
|
| uniprot:title |
Sequence analysis of the human major histocompatibility gene SX alpha.
|
| uniprot:volume |
5
|