Deposition of amyloid is the most constantly present alteration in the islets of Langerhans in type 2 diabetes mellitus and is also quite common in insulin-producing tumors of the pancreas and it is very likely that these two amyloids are identical. We have isolated amyloid fibrils from an insulin-secreting human tumour and purified the fibrillar protein. N-terminal amino acid sequence of the protein is unique and does not resemble insulin or its precursors. Instead it has about 50% homology with the neuropeptide CGRP (calcitonin gene related peptide).
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
Deposition of amyloid is the most constantly present alteration in the islets of Langerhans in type 2 diabetes mellitus and is also quite common in insulin-producing tumors of the pancreas and it is very likely that these two amyloids are identical. We have isolated amyloid fibrils from an insulin-secreting human tumour and purified the fibrillar protein. N-terminal amino acid sequence of the protein is unique and does not resemble insulin or its precursors. Instead it has about 50% homology with the neuropeptide CGRP (calcitonin gene related peptide).
|
| skos:exactMatch | |
| uniprot:name |
Biochem. Biophys. Res. Commun.
|
| uniprot:author |
Sletten K.,
Wernstedt C.,
Westermark P.,
Wilander E.
|
| uniprot:date |
1986
|
| uniprot:pages |
827-831
|
| uniprot:title |
A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas.
|
| uniprot:volume |
140
|
| dc-term:identifier |
doi:10.1016/0006-291X(86)90708-4
|