Islet or insulinoma amyloid polypeptide (IAPP) is a 37 amino acid polypeptide isolated from pancreatic amyloid. Here, we describe the isolation and partial characterization of the human gene encoding IAPP. The DNA sequence predicts that IAPP is excised from a larger precursor protein and that its carboxy-terminus is probably amidated. The predicted normally occurring IAPP is identical to the reported polypeptides isolated from pancreatic amyloid, except for the amidated carboxy-terminus. IAPP specific polyadenylated RNAs of 1.6 kb and 2.1 kb are present in human insulinoma RNA. The human IAPP gene is located on chromosome 12.
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Islet or insulinoma amyloid polypeptide (IAPP) is a 37 amino acid polypeptide isolated from pancreatic amyloid. Here, we describe the isolation and partial characterization of the human gene encoding IAPP. The DNA sequence predicts that IAPP is excised from a larger precursor protein and that its carboxy-terminus is probably amidated. The predicted normally occurring IAPP is identical to the reported polypeptides isolated from pancreatic amyloid, except for the amidated carboxy-terminus. IAPP specific polyadenylated RNAs of 1.6 kb and 2.1 kb are present in human insulinoma RNA. The human IAPP gene is located on chromosome 12.
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| uniprot:name |
FEBS Lett.
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| uniprot:author |
Geurts van Kessel A.H.M.,
Hoeppener J.W.M.,
Jansz H.S.,
Lips C.J.M.,
Mosselman S.,
Zandberg J.,
van Mansfeld A.D.M.
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| uniprot:date |
1988
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| uniprot:pages |
227-232
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| uniprot:title |
Islet amyloid polypeptide: identification and chromosomal localization of the human gene.
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| uniprot:volume |
239
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| dc-term:identifier |
doi:10.1016/0014-5793(88)80922-0
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