Interleukin-6 (IL-6/BSF-2/IFN beta 2) is a multifunctional cytokine that regulates the growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. A complementary DNA encoding the human IL-6 receptor (IL-6-R) has now been isolated. The IL-6-R consists of 468 amino acids, including a signal peptide of approximately 19 amino acids and a domain of approximately 90 amino acids that is similar to a domain in the immunoglobulin (Ig) superfamily. The cytoplasmic domain of approximately 82 amino acids lacks a tyrosine/kinase domain, unlike other growth factor receptors.
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| rdf:type | |
| rdfs:comment |
Interleukin-6 (IL-6/BSF-2/IFN beta 2) is a multifunctional cytokine that regulates the growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. A complementary DNA encoding the human IL-6 receptor (IL-6-R) has now been isolated. The IL-6-R consists of 468 amino acids, including a signal peptide of approximately 19 amino acids and a domain of approximately 90 amino acids that is similar to a domain in the immunoglobulin (Ig) superfamily. The cytoplasmic domain of approximately 82 amino acids lacks a tyrosine/kinase domain, unlike other growth factor receptors.
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| uniprot:name |
Science
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| uniprot:author |
Hirano T.,
Hirata Y.,
Kawanishi Y.,
Kishimoto T.,
Seed B.,
Taga T.,
Taniguchi T.,
Yamasaki K.,
Yawata H.
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| uniprot:date |
1988
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| uniprot:pages |
825-828
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| uniprot:title |
Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor.
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| uniprot:volume |
241
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| dc-term:identifier |
doi:10.1126/science.3136546
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