Amino-acid sequences derived from complementary DNAs encoding the alpha- and beta-subunits of the GABA/benzodiazepine receptor from bovine brain show homology with other ligand-gated receptor subunits, suggesting that there is a super-family of ion-channel-containing receptors. Co-expression of the in vitro-generated alpha-subunit and beta-subunit RNAs in Xenopus oocytes produces a functional receptor and ion channel with the pharmacological properties characteristic of the GABAA receptor.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
Amino-acid sequences derived from complementary DNAs encoding the alpha- and beta-subunits of the GABA/benzodiazepine receptor from bovine brain show homology with other ligand-gated receptor subunits, suggesting that there is a super-family of ion-channel-containing receptors. Co-expression of the in vitro-generated alpha-subunit and beta-subunit RNAs in Xenopus oocytes produces a functional receptor and ion channel with the pharmacological properties characteristic of the GABAA receptor.
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| skos:exactMatch | |
| uniprot:name |
Nature
|
| uniprot:author |
Barnard E.A.,
Burt D.R.,
Darlison M.G.,
Fujita N.,
Glencorse T.A.,
Ramachandran J.,
Reale V.,
Rhee L.M.,
Rodriguez H.,
Schofield P.R.,
Seeburg P.H.,
Stephenson F.A.
|
| uniprot:authorsIncomplete |
true
|
| uniprot:date |
1987
|
| uniprot:pages |
221-227
|
| uniprot:title |
Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor super-family.
|
| uniprot:volume |
328
|
| dc-term:identifier |
doi:10.1038/328221a0
|