An emergent clone of Haemophilus influenzae biogroup aegyptius (Hae) is responsible for outbreaks of Brazilian purpuric fever (BPF). First recorded in Brazil in 1984, the so-called BPF clone of Hae caused a fulminant disease that started with conjunctivitis but developed into septicemic shock; mortality rates were as high as 70%. To identify virulence determinants, we conducted a pan-genomic analysis. Sequencing of the genomes of the BPF clone strain F3031 and a noninvasive conjunctivitis strain, F3047, and comparison of these sequences with 5 other complete H. influenzae genomes showed that >77% of the F3031 genome is shared among all H. influenzae strains. Delineation of the Hae accessory genome enabled characterization of 163 predicted protein-coding genes; identified differences in established autotransporter adhesins; and revealed a suite of novel adhesins unique to Hae, including novel trimeric autotransporter adhesins and 4 new fimbrial operons. These novel adhesins might play a critical role in host-pathogen interactions.
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| rdf:type | |
| rdfs:comment |
An emergent clone of Haemophilus influenzae biogroup aegyptius (Hae) is responsible for outbreaks of Brazilian purpuric fever (BPF). First recorded in Brazil in 1984, the so-called BPF clone of Hae caused a fulminant disease that started with conjunctivitis but developed into septicemic shock; mortality rates were as high as 70%. To identify virulence determinants, we conducted a pan-genomic analysis. Sequencing of the genomes of the BPF clone strain F3031 and a noninvasive conjunctivitis strain, F3047, and comparison of these sequences with 5 other complete H. influenzae genomes showed that >77% of the F3031 genome is shared among all H. influenzae strains. Delineation of the Hae accessory genome enabled characterization of 163 predicted protein-coding genes; identified differences in established autotransporter adhesins; and revealed a suite of novel adhesins unique to Hae, including novel trimeric autotransporter adhesins and 4 new fimbrial operons. These novel adhesins might play a critical role in host-pathogen interactions.
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| skos:exactMatch | |
| uniprot:name |
Emerg. Infect. Dis.,
Emerging Infect. Dis.
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| uniprot:author |
Bentley S.D.,
Corton N.,
Croucher N.J.,
Hudson M.J.,
Kroll J.S.,
Langford P.R.,
Parkhill J.,
Power P.,
Quail M.A.,
Strouts F.R.,
van Tonder A.
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| uniprot:date |
2012
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| uniprot:pages |
449-457
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| uniprot:title |
Lineage-specific Virulence Determinants of Haemophilus influenzae Biogroup aegyptius.,
Lineage-specific virulence determinants of Haemophilus influenzae biogroup aegyptius.
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| uniprot:volume |
18
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| dc-term:identifier |
doi:10.3201/eid1803.110728
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