MazF is an mRNA interferase which cleaves mRNAs at a specific sequence. Here, we show that in contrast to MazF-ec from Escherichia coli, which specifically cleaves ACA sequences, MazF-bs from Bacillus subtilis is an mRNA interferase that specifically cleaves a five-base sequence, UACAU. MazF homologues widely prevailing in Gram-positive bacteria were found to be highly homologous to MazF-bs, suggesting that they may also have similar cleavage specificity. This cleavage site is over-represented in the B. subtilis genes associated with biosynthesis of secondary metabolites, suggesting that MazF-bs may be involved in the regulation of the production of secondary metabolites.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
MazF is an mRNA interferase which cleaves mRNAs at a specific sequence. Here, we show that in contrast to MazF-ec from Escherichia coli, which specifically cleaves ACA sequences, MazF-bs from Bacillus subtilis is an mRNA interferase that specifically cleaves a five-base sequence, UACAU. MazF homologues widely prevailing in Gram-positive bacteria were found to be highly homologous to MazF-bs, suggesting that they may also have similar cleavage specificity. This cleavage site is over-represented in the B. subtilis genes associated with biosynthesis of secondary metabolites, suggesting that MazF-bs may be involved in the regulation of the production of secondary metabolites.
|
| skos:exactMatch | |
| uniprot:name |
FEBS Lett.
|
| uniprot:author |
Inouye M.,
Park J.H.,
Yamaguchi Y.
|
| uniprot:date |
2011
|
| uniprot:pages |
2526-2532
|
| uniprot:title |
Bacillus subtilis MazF-bs (EndoA) is a UACAU-specific mRNA interferase.
|
| uniprot:volume |
585
|
| dc-term:identifier |
doi:10.1016/j.febslet.2011.07.008
|