Potato (Solanum tuberosum L.) is the world's most important non-grain food crop and is central to global food security. It is clonally propagated, highly heterozygous, autotetraploid, and suffers acute inbreeding depression. Here we use a homozygous doubled-monoploid potato clone to sequence and assemble 86% of the 844-megabase genome. We predict 39,031 protein-coding genes and present evidence for at least two genome duplication events indicative of a palaeopolyploid origin. As the first genome sequence of an asterid, the potato genome reveals 2,642 genes specific to this large angiosperm clade. We also sequenced a heterozygous diploid clone and show that gene presence/absence variants and other potentially deleterious mutations occur frequently and are a likely cause of inbreeding depression. Gene family expansion, tissue-specific expression and recruitment of genes to new pathways contributed to the evolution of tuber development. The potato genome sequence provides a platform for genetic improvement of this vital crop.
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Potato (Solanum tuberosum L.) is the world's most important non-grain food crop and is central to global food security. It is clonally propagated, highly heterozygous, autotetraploid, and suffers acute inbreeding depression. Here we use a homozygous doubled-monoploid potato clone to sequence and assemble 86% of the 844-megabase genome. We predict 39,031 protein-coding genes and present evidence for at least two genome duplication events indicative of a palaeopolyploid origin. As the first genome sequence of an asterid, the potato genome reveals 2,642 genes specific to this large angiosperm clade. We also sequenced a heterozygous diploid clone and show that gene presence/absence variants and other potentially deleterious mutations occur frequently and are a likely cause of inbreeding depression. Gene family expansion, tissue-specific expression and recruitment of genes to new pathways contributed to the evolution of tuber development. The potato genome sequence provides a platform for genetic improvement of this vital crop.
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Nature
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Skryabin K.G.,
Xu J.,
Visser R.G.,
Ghislain M.,
Wang J.,
Huang S.,
Li Y.,
Jiang J.,
Zhang Z.,
He J.,
Cheng S.,
Yang Y.,
Zhang Y.,
DellaPenna D.,
Li G.,
Xie B.,
Nagy I.,
Sharma S.K.,
Du Y.,
Torres M.,
Zhang G.,
Xu X.,
Hu Q.,
Buell C.R.,
Li R.,
Zhang B.,
Lin H.,
van Ham R.C.,
Waugh R.,
O'Brien K.,
Zagorski W.,
He Y.,
van Eck H.,
Lozano R.,
Jacobs J.M.,
Giuliano G.,
Gromadka R.,
Sagredo B.,
Nielsen K.L.,
Pan S.,
Liang C.,
Mu D.,
Yang S.,
Martin D.M.,
Qu D.,
Martinez D.,
Xiong X.,
Bachem C.W.,
Bishop G.J.,
Perrotta G.,
Guzman F.,
de Boer J.,
Kuang H.,
Marshall D.F.,
Goverse A.,
Kuznetsov B.B.,
Ni P.,
Fiers M.,
Chakrabarti S.K.,
Mejia N.,
Torres G.A.,
Bryan G.J.,
Milbourne D.,
Kolganova T.V.,
Whitty B.R.,
Massa G.A.,
Facella P.,
Massa A.N.,
Orjeda G.,
Kloosterman B.,
Mardanov A.V.,
Ravin N.V.,
Feingold S.E.,
Thomson S.J.,
Szczesny P.,
Beletsky A.V.,
Diambra L.,
Veilleux R.E.,
Sonderkaer M.,
Ponce O.,
De la Cruz G.,
Patil V.U.,
Di Genova A.,
Bolser D.M.,
Gawor J.,
Bonierbale M.,
Herrera M.d.e.l. R.,
Pietrella M.,
Barreiro L.E.,
Vaillancourt B.,
Geoffroy M.,
Lundback S.,
Destefanis M.,
Iovene M.,
Borm T.,
Datema E.
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