The human intestine is densely populated by a microbial consortium whose metabolic activities are influenced by, among others, bifidobacteria. However, the genetic basis of adaptation of bifidobacteria to the human gut is poorly understood. Analysis of the 2,214,650-bp genome of Bifidobacterium bifidum PRL2010, a strain isolated from infant stool, revealed a nutrient-acquisition strategy that targets host-derived glycans, such as those present in mucin. Proteome and transcriptome profiling revealed a set of chromosomal loci responsible for mucin metabolism that appear to be under common transcriptional control and with predicted functions that allow degradation of various O-linked glycans in mucin. Conservation of the latter gene clusters in various B. bifidum strains supports the notion that host-derived glycan catabolism is an important colonization factor for B. bifidum with concomitant impact on intestinal microbiota ecology.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
The human intestine is densely populated by a microbial consortium whose metabolic activities are influenced by, among others, bifidobacteria. However, the genetic basis of adaptation of bifidobacteria to the human gut is poorly understood. Analysis of the 2,214,650-bp genome of Bifidobacterium bifidum PRL2010, a strain isolated from infant stool, revealed a nutrient-acquisition strategy that targets host-derived glycans, such as those present in mucin. Proteome and transcriptome profiling revealed a set of chromosomal loci responsible for mucin metabolism that appear to be under common transcriptional control and with predicted functions that allow degradation of various O-linked glycans in mucin. Conservation of the latter gene clusters in various B. bifidum strains supports the notion that host-derived glycan catabolism is an important colonization factor for B. bifidum with concomitant impact on intestinal microbiota ecology.
|
| skos:exactMatch | |
| uniprot:name |
Proc. Natl. Acad. Sci. U.S.A.
|
| uniprot:author |
Bidossi A.,
Bottacini F.,
Coutinho P.,
Delledonne M.,
Ferrarini A.,
Fitzgerald G.F.,
Foroni E.,
Giubellini V.,
Henrissat B.,
Kelly D.,
Kim J.H.,
Margolles A.,
Mills D.,
Mulder I.,
Oggioni M.,
Sanchez B.,
Turroni F.,
Ventura M.,
Zomer A.,
van Sinderen D.
|
| uniprot:date |
2010
|
| uniprot:pages |
19514-19519
|
| uniprot:title |
Genome analysis of Bifidobacterium bifidum PRL2010 reveals metabolic pathways for host-derived glycan foraging.
|
| uniprot:volume |
107
|
| dc-term:identifier |
doi:10.1073/pnas.1011100107
|