The murine oct-3 gene encodes a transcription factor containing a POU-specific domain and a homeodomain. In marked contrast to other homeodomain-encoding genes, oct-3 is expressed in the totipotent and pluripotent stem cells of the pregastrulation embryo and is down-regulated during differentiation to endoderm and mesoderm, suggesting that it has a role in early development. The oct-3 gene is also expressed in primordial germ cells and in the female germ line.
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| rdf:type | |
| rdfs:comment |
The murine oct-3 gene encodes a transcription factor containing a POU-specific domain and a homeodomain. In marked contrast to other homeodomain-encoding genes, oct-3 is expressed in the totipotent and pluripotent stem cells of the pregastrulation embryo and is down-regulated during differentiation to endoderm and mesoderm, suggesting that it has a role in early development. The oct-3 gene is also expressed in primordial germ cells and in the female germ line.
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| skos:exactMatch | |
| uniprot:name |
Nature
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| uniprot:author |
Ozato K.,
Poirier F.,
Rigby P.W.J.,
Rosner M.H.,
Staudt L.,
Timmons P.M.,
Vigano M.A.
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| uniprot:date |
1990
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| uniprot:pages |
686-692
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| uniprot:title |
A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo.
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| uniprot:volume |
345
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| dc-term:identifier |
doi:10.1038/345686a0
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