Type 2C protein phosphatases (PP2Cs) are vitally involved in abscisic acid (ABA) signaling. Here, we show that a synthetic growth inhibitor called pyrabactin functions as a selective ABA agonist. Pyrabactin acts through PYRABACTIN RESISTANCE 1 (PYR1), the founding member of a family of START proteins called PYR/PYLs, which are necessary for both pyrabactin and ABA signaling in vivo. We show that ABA binds to PYR1, which in turn binds to and inhibits PP2Cs. We conclude that PYR/PYLs are ABA receptors functioning at the apex of a negative regulatory pathway that controls ABA signaling by inhibiting PP2Cs. Our results illustrate the power of the chemical genetic approach for sidestepping genetic redundancy.
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| rdf:type | |
| rdfs:comment |
Type 2C protein phosphatases (PP2Cs) are vitally involved in abscisic acid (ABA) signaling. Here, we show that a synthetic growth inhibitor called pyrabactin functions as a selective ABA agonist. Pyrabactin acts through PYRABACTIN RESISTANCE 1 (PYR1), the founding member of a family of START proteins called PYR/PYLs, which are necessary for both pyrabactin and ABA signaling in vivo. We show that ABA binds to PYR1, which in turn binds to and inhibits PP2Cs. We conclude that PYR/PYLs are ABA receptors functioning at the apex of a negative regulatory pathway that controls ABA signaling by inhibiting PP2Cs. Our results illustrate the power of the chemical genetic approach for sidestepping genetic redundancy.
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| skos:exactMatch | |
| uniprot:name |
Science
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| uniprot:author |
Alfred S.E.,
Bonetta D.,
Chow T.F.,
Cutler S.R.,
Desveaux D.,
Finkelstein R.,
Fujii H.,
Fung P.,
Jensen D.R.,
Lumba S.,
McCourt P.,
Nishimura N.,
Park S.-Y.,
Provart N.J.,
Rodrigues A.,
Rodriguez P.L.,
Santiago J.,
Schroeder J.I.,
Volkman B.F.,
Zhao Y.,
Zhu J.-K.
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| uniprot:date |
2009
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| uniprot:pages |
1068-1071
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| uniprot:title |
Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins.
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| uniprot:volume |
324
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| dc-term:identifier |
doi:10.1126/science.1173041
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