We isolated a temperature-sensitive mutant with a mutation in mviN, an essential gene in Escherichia coli. At the nonpermissive temperature, mviN mutant cells swelled and burst. An intermediate in murein synthesis, polyprenyl diphosphate-N-acetylmuramic acid-(pentapeptide)-N-acetyl-glucosamine, accumulated in mutant cells. These results indicated that MviN is involved in murein synthesis.
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| rdf:type | |
| rdfs:comment |
We isolated a temperature-sensitive mutant with a mutation in mviN, an essential gene in Escherichia coli. At the nonpermissive temperature, mviN mutant cells swelled and burst. An intermediate in murein synthesis, polyprenyl diphosphate-N-acetylmuramic acid-(pentapeptide)-N-acetyl-glucosamine, accumulated in mutant cells. These results indicated that MviN is involved in murein synthesis.
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| skos:exactMatch | |
| uniprot:name |
J. Bacteriol.
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| uniprot:author |
Fujisaki S.,
Inoue A.,
Kato J.,
Murata Y.,
Takahashi H.,
Tsuji N.
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| uniprot:date |
2008
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| uniprot:pages |
7298-7301
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| uniprot:title |
Involvement of an essential gene, mviN, in murein synthesis in Escherichia coli.
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| uniprot:volume |
190
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| dc-term:identifier |
doi:10.1128/JB.00551-08
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