We report a previously uncharacterized CHHC Zn-finger domain identified in spliceosomal U11-48K proteins, tRNA methyl-transferases TRM13 and gametocyte specific factors. We show that this domain behaves as an independent folding unit and that it stoichiometrically binds zinc in a one-to-one ratio. Based on the conserved sequence features we predict that this domain may function as a RNA recognition and binding module.
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| rdf:type | |
| rdfs:comment |
We report a previously uncharacterized CHHC Zn-finger domain identified in spliceosomal U11-48K proteins, tRNA methyl-transferases TRM13 and gametocyte specific factors. We show that this domain behaves as an independent folding unit and that it stoichiometrically binds zinc in a one-to-one ratio. Based on the conserved sequence features we predict that this domain may function as a RNA recognition and binding module.
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| skos:exactMatch | |
| uniprot:name |
Bioinformatics
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| uniprot:author |
Andreeva A.,
Tidow H.
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| uniprot:date |
2008
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| uniprot:pages |
2277-2280
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| uniprot:title |
A novel CHHC Zn-finger domain found in spliceosomal proteins and tRNA modifying enzymes.
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| uniprot:volume |
24
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| dc-term:identifier |
doi:10.1093/bioinformatics/btn431
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