We sequenced and annotated the genome of the filamentous fungus Fusarium graminearum, a major pathogen of cultivated cereals. Very few repetitive sequences were detected, and the process of repeat-induced point mutation, in which duplicated sequences are subject to extensive mutation, may partially account for the reduced repeat content and apparent low number of paralogous (ancestrally duplicated) genes. A second strain of F. graminearum contained more than 10,000 single-nucleotide polymorphisms, which were frequently located near telomeres and within other discrete chromosomal segments. Many highly polymorphic regions contained sets of genes implicated in plant-fungus interactions and were unusually divergent, with higher rates of recombination. These regions of genome innovation may result from selection due to interactions of F. graminearum with its plant hosts.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
We sequenced and annotated the genome of the filamentous fungus Fusarium graminearum, a major pathogen of cultivated cereals. Very few repetitive sequences were detected, and the process of repeat-induced point mutation, in which duplicated sequences are subject to extensive mutation, may partially account for the reduced repeat content and apparent low number of paralogous (ancestrally duplicated) genes. A second strain of F. graminearum contained more than 10,000 single-nucleotide polymorphisms, which were frequently located near telomeres and within other discrete chromosomal segments. Many highly polymorphic regions contained sets of genes implicated in plant-fungus interactions and were unusually divergent, with higher rates of recombination. These regions of genome innovation may result from selection due to interactions of F. graminearum with its plant hosts.
|
| skos:exactMatch | |
| uniprot:name |
Science
|
| uniprot:author |
Adam G.,
Antoniw J.,
Baker S.E.,
Baldwin T.,
Birren B.W.,
Calvo S.E.,
Chang Y.-L.,
Cuomo C.A.,
DeCaprio D.,
Di Pietro A.,
Gale L.R.,
Gnerre S.,
Goswami R.S.,
Gueldener U.,
Hammond-Kosack K.,
Harris L.J.,
Hilburn K.,
Kennell J.C.,
Kistler H.C.,
Kroken S.,
Ma L.-J.,
Magnuson J.K.,
Mannhaupt G.,
Mauceli E.W.,
Mewes H.-W.,
Mitterbauer R.,
Muehlbauer G.,
Muensterkoetter M.,
Nelson D.,
O'Donnell K.,
Ouellet T.,
Qi W.,
Quesneville H.,
Rep M.,
Roncero M.I.G.,
Seong K.-Y.,
Tetko I.V.,
Trail F.,
Turgeon B.G.,
Urban M.,
Waalwijk C.,
Walton J.D.,
Ward T.J.,
Xu J.-R.,
Yao J.
|
| uniprot:date |
2007
|
| uniprot:pages |
1400-1402
|
| uniprot:title |
The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.
|
| uniprot:volume |
317
|
| dc-term:identifier |
doi:10.1126/science.1143708
|