DNA methylation systems are well characterized in vertebrates, but methylation in Drosophila melanogaster and other invertebrates remains controversial. Using the recently sequenced honey bee genome, we present a bioinformatic, molecular, and biochemical characterization of a functional DNA methylation system in an insect. We report on catalytically active orthologs of the vertebrate DNA methyltransferases Dnmt1 and Dnmt3a and b, two isoforms that contain a methyl-DNA binding domain, genomic 5-methyl-deoxycytosine, and CpG-methylated genes. The honey bee provides an opportunity to study the roles of methylation in social contexts.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
DNA methylation systems are well characterized in vertebrates, but methylation in Drosophila melanogaster and other invertebrates remains controversial. Using the recently sequenced honey bee genome, we present a bioinformatic, molecular, and biochemical characterization of a functional DNA methylation system in an insect. We report on catalytically active orthologs of the vertebrate DNA methyltransferases Dnmt1 and Dnmt3a and b, two isoforms that contain a methyl-DNA binding domain, genomic 5-methyl-deoxycytosine, and CpG-methylated genes. The honey bee provides an opportunity to study the roles of methylation in social contexts.
|
| skos:exactMatch | |
| uniprot:name |
Science
|
| uniprot:author |
Jones P.L.,
Jorda M.,
Ling X.,
Maleszka R.,
Mizzen C.A.,
Peinado M.A.,
Robertson H.M.,
Robinson G.E.,
Wang Y.
|
| uniprot:date |
2006
|
| uniprot:pages |
645-647
|
| uniprot:title |
Functional CpG methylation system in a social insect.
|
| uniprot:volume |
314
|
| dc-term:identifier |
doi:10.1126/science.1135213
|