The RSC chromatin-remodeling complex completely disassembles a nucleosome in the presence of the histone chaperone Nap1 and ATP. Disassembly occurs in a stepwise manner, with the removal of H2A/H2B dimers, followed by the rest of the histones and the release of naked DNA. RSC and related chromatin-remodeling complexes may be responsible for the removal of promoter nucleosomes during transcriptional activation in vivo.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
The RSC chromatin-remodeling complex completely disassembles a nucleosome in the presence of the histone chaperone Nap1 and ATP. Disassembly occurs in a stepwise manner, with the removal of H2A/H2B dimers, followed by the rest of the histones and the release of naked DNA. RSC and related chromatin-remodeling complexes may be responsible for the removal of promoter nucleosomes during transcriptional activation in vivo.
|
| skos:exactMatch | |
| uniprot:name |
Proc. Natl. Acad. Sci. U.S.A.
|
| uniprot:author |
Kornberg R.D.,
Lorch Y.,
Maier-Davis B.
|
| uniprot:date |
2006
|
| uniprot:pages |
3090-3093
|
| uniprot:title |
Chromatin remodeling by nucleosome disassembly in vitro.
|
| uniprot:volume |
103
|
| dc-term:identifier |
doi:10.1073/pnas.0511050103
|