Here we present a system for adenovirus detection and genotyping based on PCR amplification and phylogenetic analysis of a conserved hexon gene fragment. The system was validated using 157 sequences (86 previously typed and 71 clinical samples) and correctly identified species and serotype in 100% and 84% of sequences, respectively. Known associations between specific serotypes and clinical syndromes are verified. Possible new associations are described to allow further independent testing.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
Here we present a system for adenovirus detection and genotyping based on PCR amplification and phylogenetic analysis of a conserved hexon gene fragment. The system was validated using 157 sequences (86 previously typed and 71 clinical samples) and correctly identified species and serotype in 100% and 84% of sequences, respectively. Known associations between specific serotypes and clinical syndromes are verified. Possible new associations are described to allow further independent testing.
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| skos:exactMatch | |
| uniprot:name |
J. Clin. Microbiol.
|
| uniprot:author |
Avellon A.,
Campos R.H.,
Casas I.,
Echevarria J.E.,
Jabado O.,
Lipkin W.I.,
Mosquera M.,
Palacios G.,
Perez-Brena P.,
Rewers M.
|
| uniprot:date |
2005
|
| uniprot:pages |
6176-6182
|
| uniprot:title |
Molecular identification of adenoviruses in clinical samples by analyzing a partial hexon genomic region.
|
| uniprot:volume |
43
|
| dc-term:identifier |
doi:10.1128/JCM.43.12.6176-6182.2005
|