The SWI/SNF-like chromatin remodeling complex of Drosophila, the Brahma complex, contains four subunits (Brahma, BAP155/Moira, SNR1 and BAP60) conserved from yeast to humans. A reconstituted human complex lacking the BAP60 homolog shows full remodeling activity, suggesting that BAP60 is not essential for the core function. We generated Drosophila mutants and found that BAP60 carries a vital function and participates in complex-mediated transcriptional activation and repression. BAP60 binds DNA and shows genetic and physical interactions with the sex-determining transcription factors encoded by sisterless A and scute. The results support the conclusion that BAP60 participates in site-specific recruitment of the Brahma complex in Drosophila.
| Predicate | Object |
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| rdf:type | |
| rdfs:comment |
The SWI/SNF-like chromatin remodeling complex of Drosophila, the Brahma complex, contains four subunits (Brahma, BAP155/Moira, SNR1 and BAP60) conserved from yeast to humans. A reconstituted human complex lacking the BAP60 homolog shows full remodeling activity, suggesting that BAP60 is not essential for the core function. We generated Drosophila mutants and found that BAP60 carries a vital function and participates in complex-mediated transcriptional activation and repression. BAP60 binds DNA and shows genetic and physical interactions with the sex-determining transcription factors encoded by sisterless A and scute. The results support the conclusion that BAP60 participates in site-specific recruitment of the Brahma complex in Drosophila.
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| skos:exactMatch | |
| uniprot:name |
J. Mol. Biol.
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| uniprot:author |
Avila F.W.,
Erickson J.W.,
Jackle H.,
Moller A.
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| uniprot:date |
2005
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| uniprot:pages |
329-337
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| uniprot:title |
Drosophila BAP60 is an essential component of the Brahma complex, required for gene activation and repression.
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| uniprot:volume |
352
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| dc-term:identifier |
doi:10.1016/j.jmb.2005.07.009
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