Plants possess a sophisticated sugar biosynthetic machinery comprising families of nucleotide sugar interconversion enzymes. Literature published in the past two years has made a major contribution to our knowledge of the enzymes and genes involved in the interconversion of nucleotide sugars that are required for cell wall biosynthesis, including UDP-L-rhamnose, UDP-D-galactose, UDP-D-glucuronic acid, UDP-D-xylose, UDP-D-apiose, UDP-L-arabinose, GDP-L-fucose and GDP-L-galactose. Indirect evidence suggests that enzyme activity is crudely regulated at the transcriptional level in a cell-type and differentiation-dependent manner. However, feedback inhibition and NAD(+)/NADH redox control, as well as the formation of complexes between differentially encoded isoforms and glycosyltransferases, might fine-tune cell wall matrix biosynthesis. I hypothesise that the control of nucleotide sugar interconversion enzymes regulates glycosylation patterns in response to developmental, metabolic and stress-related stimuli, thereby linking signalling with primary metabolism and the dynamics of the extracellular matrix.
| Predicate | Object |
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| rdf:type | |
| rdfs:comment |
Plants possess a sophisticated sugar biosynthetic machinery comprising families of nucleotide sugar interconversion enzymes. Literature published in the past two years has made a major contribution to our knowledge of the enzymes and genes involved in the interconversion of nucleotide sugars that are required for cell wall biosynthesis, including UDP-L-rhamnose, UDP-D-galactose, UDP-D-glucuronic acid, UDP-D-xylose, UDP-D-apiose, UDP-L-arabinose, GDP-L-fucose and GDP-L-galactose. Indirect evidence suggests that enzyme activity is crudely regulated at the transcriptional level in a cell-type and differentiation-dependent manner. However, feedback inhibition and NAD(+)/NADH redox control, as well as the formation of complexes between differentially encoded isoforms and glycosyltransferases, might fine-tune cell wall matrix biosynthesis. I hypothesise that the control of nucleotide sugar interconversion enzymes regulates glycosylation patterns in response to developmental, metabolic and stress-related stimuli, thereby linking signalling with primary metabolism and the dynamics of the extracellular matrix.
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| skos:exactMatch | |
| uniprot:name |
Curr. Opin. Plant Biol.
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| uniprot:author |
Seifert G.J.
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| uniprot:date |
2004
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| uniprot:pages |
277-284
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| uniprot:title |
Nucleotide sugar interconversions and cell wall biosynthesis: how to bring the inside to the outside.
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| uniprot:volume |
7
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| dc-term:identifier |
doi:10.1016/j.pbi.2004.03.004
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