We present the diploid genome sequence of the fungal pathogen Candida albicans. Because C. albicans has no known haploid or homozygous form, sequencing was performed as a whole-genome shotgun of the heterozygous diploid genome in strain SC5314, a clinical isolate that is the parent of strains widely used for molecular analysis. We developed computational methods to assemble a diploid genome sequence in good agreement with available physical mapping data. We provide a whole-genome description of heterozygosity in the organism. Comparative genomic analyses provide important clues about the evolution of the species and its mechanisms of pathogenesis.
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We present the diploid genome sequence of the fungal pathogen Candida albicans. Because C. albicans has no known haploid or homozygous form, sequencing was performed as a whole-genome shotgun of the heterozygous diploid genome in strain SC5314, a clinical isolate that is the parent of strains widely used for molecular analysis. We developed computational methods to assemble a diploid genome sequence in good agreement with available physical mapping data. We provide a whole-genome description of heterozygosity in the organism. Comparative genomic analyses provide important clues about the evolution of the species and its mechanisms of pathogenesis.
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| uniprot:name |
Proc. Natl. Acad. Sci. U.S.A.
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| uniprot:author |
Agabian N.,
Chibana H.,
Davis R.W.,
Dungan J.,
Federspiel N.A.,
Jones T.,
Kalman S.,
Magee B.B.,
Magee P.T.,
Newport G.,
Scherer S.,
Thorstenson Y.R.
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| uniprot:date |
2004
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| uniprot:pages |
7329-7334
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| uniprot:title |
The diploid genome sequence of Candida albicans.
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| uniprot:volume |
101
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| dc-term:identifier |
doi:10.1073/pnas.0401648101
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