Microbiology

In this study, the genetic relationship of 19 Porphyromonas gingivalis isolates from patients with periodontitis was investigated by multilocus sequence analysis. Internal 400-600 bp DNA fragments of the 10 chromosomal genes ef-tu, ftsQ, hagB, gpdxJ, pepO, mcmA, dnaK, recA, pga and nah were amplified by PCR and sequenced. No two isolates were identical at all 10 loci. Phylogenetic analyses indicated a panmictic population structure of P. gingivalis. Split decomposition analysis, calculation of homoplasy ratios and analyses of clustered polymorphisms all indicate that recombination plays a major role in creating the genetic heterogeneity of P. gingivalis. A standardized index of association of 0.0898 indicates that the P. gingivalis genes analysed are close to linkage equilibrium.

Source:http://purl.uniprot.org/citations/12949166

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Predicate	Object
rdf:type	uniprot:Journal_Citation
rdfs:comment	In this study, the genetic relationship of 19 Porphyromonas gingivalis isolates from patients with periodontitis was investigated by multilocus sequence analysis. Internal 400-600 bp DNA fragments of the 10 chromosomal genes ef-tu, ftsQ, hagB, gpdxJ, pepO, mcmA, dnaK, recA, pga and nah were amplified by PCR and sequenced. No two isolates were identical at all 10 loci. Phylogenetic analyses indicated a panmictic population structure of P. gingivalis. Split decomposition analysis, calculation of homoplasy ratios and analyses of clustered polymorphisms all indicate that recombination plays a major role in creating the genetic heterogeneity of P. gingivalis. A standardized index of association of 0.0898 indicates that the P. gingivalis genes analysed are close to linkage equilibrium.
skos:exactMatch	http://purl.uniprot.org/medline/22830417, http://purl.uniprot.org/pubmed/12949166
uniprot:name	Microbiology, Microbiology (Reading, Engl.)
uniprot:author	Beikler T., Flemmig T.F., Karch H., Koehler A., Schmidt H., Suerbaum S.
uniprot:date	2003
uniprot:pages	2407-2415
uniprot:title	Multilocus sequence analysis of Porphyromonas gingivalis indicates frequent recombination.
uniprot:volume	149
dc-term:identifier	doi:10.1099/mic.0.26267-0