The human gut is colonized with a vast community of indigenous microorganisms that help shape our biology. Here, we present the complete genome sequence of the Gram-negative anaerobe Bacteroides thetaiotaomicron, a dominant member of our normal distal intestinal microbiota. Its 4779-member proteome includes an elaborate apparatus for acquiring and hydrolyzing otherwise indigestible dietary polysaccharides and an associated environment-sensing system consisting of a large repertoire of extracytoplasmic function sigma factors and one- and two-component signal transduction systems. These and other expanded paralogous groups shed light on the molecular mechanisms underlying symbiotic host-bacterial relationships in our intestine.
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| rdfs:comment |
The human gut is colonized with a vast community of indigenous microorganisms that help shape our biology. Here, we present the complete genome sequence of the Gram-negative anaerobe Bacteroides thetaiotaomicron, a dominant member of our normal distal intestinal microbiota. Its 4779-member proteome includes an elaborate apparatus for acquiring and hydrolyzing otherwise indigestible dietary polysaccharides and an associated environment-sensing system consisting of a large repertoire of extracytoplasmic function sigma factors and one- and two-component signal transduction systems. These and other expanded paralogous groups shed light on the molecular mechanisms underlying symbiotic host-bacterial relationships in our intestine.
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| uniprot:name |
Science
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| uniprot:author |
Bjursell M.K.,
Carmichael L.K.,
Chiang H.C.,
Deng S.,
Gordon J.I.,
Himrod J.,
Hooper L.V.,
Xu J.
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| uniprot:date |
2003
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| uniprot:pages |
2074-2076
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| uniprot:title |
A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.
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| uniprot:volume |
299
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| dc-term:identifier |
doi:10.1126/science.1080029
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