The angiopoietins are an important family of growth factors specific for vascular endothelium. Most of them bind to the TIE2 receptor and are related to regulation of angiogenesis. During large-scale DNA sequencing of the human fetal brain cDNA library, we cloned a novel human angiopoietin-like cDNA and termed it human angiopoietin-like 5 ( ANGPTL5). Like other members of the angiopoietin family, ANGPTL5-deduced protein also has an N-terminal cleavable signal peptide, a predicted coiled-coil domain, and a fibrinogen-like domain. The search against the human genome database indicated that ANGPTL5 maps to 11q22. Expression analysis of ANGPTL5 shows that it is mainly expressed in adult human heart.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
The angiopoietins are an important family of growth factors specific for vascular endothelium. Most of them bind to the TIE2 receptor and are related to regulation of angiogenesis. During large-scale DNA sequencing of the human fetal brain cDNA library, we cloned a novel human angiopoietin-like cDNA and termed it human angiopoietin-like 5 ( ANGPTL5). Like other members of the angiopoietin family, ANGPTL5-deduced protein also has an N-terminal cleavable signal peptide, a predicted coiled-coil domain, and a fibrinogen-like domain. The search against the human genome database indicated that ANGPTL5 maps to 11q22. Expression analysis of ANGPTL5 shows that it is mainly expressed in adult human heart.
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| skos:exactMatch | |
| uniprot:name |
J. Hum. Genet.
|
| uniprot:author |
Dai J.,
Dai J.',
Jin W.,
Mao Y.,
Xie Y.,
Xu J.,
Ye Y.,
Ying K.,
Zeng L.,
Zhao E.
|
| uniprot:date |
2003
|
| uniprot:pages |
159-162
|
| uniprot:title |
Identification of a novel human angiopoietin-like gene expressed mainly in heart.
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| uniprot:volume |
48
|
| dc-term:identifier |
doi:10.1007/s100380300025
|