Neuronal connectivity is established by the axo-dendritic polarity, correct guidance and targeting of neurons. Unlike for axons, the mechanisms responsible for directed outgrowth of dendrites are not well understood. Using single-cell labeling, we describe specific guidance defects in dendrites of identified neurons in frazzled, robo, netrin and commissureless mutant embryos of Drosophila melanogaster. We found that the cell-surface molecules Frazzled and Robo work as guidance molecules not only for axons but also for dendrites as they navigate within the CNS. Furthermore, we report that each neuron showed a cell-autonomous and independent use of guidance molecules.
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| rdf:type | |
| rdfs:comment |
Neuronal connectivity is established by the axo-dendritic polarity, correct guidance and targeting of neurons. Unlike for axons, the mechanisms responsible for directed outgrowth of dendrites are not well understood. Using single-cell labeling, we describe specific guidance defects in dendrites of identified neurons in frazzled, robo, netrin and commissureless mutant embryos of Drosophila melanogaster. We found that the cell-surface molecules Frazzled and Robo work as guidance molecules not only for axons but also for dendrites as they navigate within the CNS. Furthermore, we report that each neuron showed a cell-autonomous and independent use of guidance molecules.
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| skos:exactMatch | |
| uniprot:name |
Nat. Neurosci.
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| uniprot:author |
Chiba A.,
Furrer M.P.,
Kim S.,
Wolf B.
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| uniprot:date |
2003
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| uniprot:pages |
223-230
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| uniprot:title |
Robo and Frazzled/DCC mediate dendritic guidance at the CNS midline.
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| uniprot:volume |
6
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| dc-term:identifier |
doi:10.1038/nn1017
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