Staphyllococcus aureus-induced infections often result in high mortality and permanent joint destruction, despite treatment with antibiotics. IL-10 is typically regarded as an anti-inflammatory cytokine because it promotes a T helper cell type 2 response, and subsequently down-regulates cell mediated immune functions. To investigate the role of IL-10 in S. aureus-induced arthritis and sepsis, Balb/c mice, intact or defective with respect to IL-10 gene were intravenously inoculated with bacteria. IL-10-/-mice develop a more frequent and destructive arthritis compared to their congeneic controls. The mechanisms regulating such outcome may be due not only to the anti-inflammatory properties of IL-10 but also, directly or indirectly, to antibacterial features of this molecule. Indeed, inoculation of staphylococci to IL-10-/-mice resulted in higher bacterial load in blood and kidneys compared to congeneic controls. Altogether our data indicate that IL-10 is essential for efficient elimination of bacteria and thereby for protection against septic arthritis.
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| rdf:type | |
| rdfs:comment |
Staphyllococcus aureus-induced infections often result in high mortality and permanent joint destruction, despite treatment with antibiotics. IL-10 is typically regarded as an anti-inflammatory cytokine because it promotes a T helper cell type 2 response, and subsequently down-regulates cell mediated immune functions. To investigate the role of IL-10 in S. aureus-induced arthritis and sepsis, Balb/c mice, intact or defective with respect to IL-10 gene were intravenously inoculated with bacteria. IL-10-/-mice develop a more frequent and destructive arthritis compared to their congeneic controls. The mechanisms regulating such outcome may be due not only to the anti-inflammatory properties of IL-10 but also, directly or indirectly, to antibacterial features of this molecule. Indeed, inoculation of staphylococci to IL-10-/-mice resulted in higher bacterial load in blood and kidneys compared to congeneic controls. Altogether our data indicate that IL-10 is essential for efficient elimination of bacteria and thereby for protection against septic arthritis.
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| skos:exactMatch | |
| uniprot:name |
Clin. Exp. Immunol.
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| uniprot:author |
Gjertsson I.,
Hultgren O.H.,
Tarkowski A.
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| uniprot:date |
2002
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| uniprot:pages |
409-414
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| uniprot:title |
Interleukin-10 ameliorates the outcome of Staphylococcus aureus arthritis by promoting bacterial clearance.
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| uniprot:volume |
130
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| dc-term:identifier |
doi:10.1046/j.1365-2249.2002.01999.x
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