We used bioinformatic approaches to identify a total of 276 G protein-coupled receptors (GPCRs) from the Anopheles gambiae genome. These include GPCRs that are likely to play roles in pathways affecting almost every aspect of the mosquito's life cycle. Seventy-nine candidate odorant receptors were characterized for tissue expression and, along with 76 putative gustatory receptors, for their molecular evolution relative to Drosophila melanogaster. Examples of lineage-specific gene expansions were observed as well as a single instance of unusually high sequence conservation.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
We used bioinformatic approaches to identify a total of 276 G protein-coupled receptors (GPCRs) from the Anopheles gambiae genome. These include GPCRs that are likely to play roles in pathways affecting almost every aspect of the mosquito's life cycle. Seventy-nine candidate odorant receptors were characterized for tissue expression and, along with 76 putative gustatory receptors, for their molecular evolution relative to Drosophila melanogaster. Examples of lineage-specific gene expansions were observed as well as a single instance of unusually high sequence conservation.
|
| skos:exactMatch | |
| uniprot:name |
Science
|
| uniprot:author |
Chrystal M.A.,
Collins F.H.,
Cravchik A.,
Fox A.N.,
Hill C.A.,
Kent L.B.,
Pitts R.J.,
Robertson H.M.,
Tan P.L.,
Zwiebel L.J.
|
| uniprot:date |
2002
|
| uniprot:pages |
176-178
|
| uniprot:title |
G protein-coupled receptors in Anopheles gambiae.
|
| uniprot:volume |
298
|
| dc-term:identifier |
doi:10.1126/science.1076196
|