Nat. Neurosci.

Controlling the number of functional gamma-aminobutyric acid A (GABA(A)) receptors in neuronal membranes is a crucial factor for the efficacy of inhibitory neurotransmission. Here we describe the direct interaction of GABA(A) receptors with the ubiquitin-like protein Plic-1. Furthermore, Plic-1 is enriched at inhibitory synapses and is associated with subsynaptic membranes. Functionally, Plic-1 facilitates GABA(A) receptor cell surface expression without affecting the rate of receptor internalization. Plic-1 also enhances the stability of intracellular GABA(A) receptor subunits, increasing the number of receptors available for insertion into the plasma membrane. Our study identifies a previously unknown role for Plic-1, a modulation of GABA(A) receptor cell surface number, which suggests that Plic-1 facilitates accumulation of these receptors in dendritic membranes.

Source:http://purl.uniprot.org/citations/11528422

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Predicate	Object
rdf:type	uniprot:Journal_Citation
rdfs:comment	Controlling the number of functional gamma-aminobutyric acid A (GABA(A)) receptors in neuronal membranes is a crucial factor for the efficacy of inhibitory neurotransmission. Here we describe the direct interaction of GABA(A) receptors with the ubiquitin-like protein Plic-1. Furthermore, Plic-1 is enriched at inhibitory synapses and is associated with subsynaptic membranes. Functionally, Plic-1 facilitates GABA(A) receptor cell surface expression without affecting the rate of receptor internalization. Plic-1 also enhances the stability of intracellular GABA(A) receptor subunits, increasing the number of receptors available for insertion into the plasma membrane. Our study identifies a previously unknown role for Plic-1, a modulation of GABA(A) receptor cell surface number, which suggests that Plic-1 facilitates accumulation of these receptors in dendritic membranes.
skos:exactMatch	http://purl.uniprot.org/medline/21419682, http://purl.uniprot.org/pubmed/11528422
uniprot:name	Nat. Neurosci.
uniprot:author	Bedford F.K., Kittler J.T., Merlo D., Moss S.J., Muller E., Smart T.G., Thomas P., Triller A., Uren J.M., Wisden W.
uniprot:date	2001
uniprot:pages	908-916
uniprot:title	GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1.
uniprot:volume	4
dc-term:identifier	doi:10.1038/nn0901-908