The public availability of numerous microbial genomes is enabling the analysis of bacterial biology in great detail and with an unprecedented, organism-wide and taxon-wide, broad scope. Streptococcus pneumoniae is one of the most important bacterial pathogens throughout the world. We present here sequences and functional annotations for 2.1-Mbp of pneumococcal DNA, covering more than 90% of the total estimated size of the genome. The sequenced strain is a clinical isolate resistant to macrolides and tetracycline. It carries a type 19F capsular locus, but multilocus sequence typing for several conserved genetic loci suggests that the strain sequenced belongs to a pneumococcal lineage that most often expresses a serotype 15 capsular polysaccharide. A total of 2,046 putative open reading frames (ORFs) longer than 100 amino acids were identified (average of 1,009 bp per ORF), including all described two-component systems and aminoacyl tRNA synthetases. Comparisons to other complete, or nearly complete, bacterial genomes were made and are presented in a graphical form for all the predicted proteins.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
The public availability of numerous microbial genomes is enabling the analysis of bacterial biology in great detail and with an unprecedented, organism-wide and taxon-wide, broad scope. Streptococcus pneumoniae is one of the most important bacterial pathogens throughout the world. We present here sequences and functional annotations for 2.1-Mbp of pneumococcal DNA, covering more than 90% of the total estimated size of the genome. The sequenced strain is a clinical isolate resistant to macrolides and tetracycline. It carries a type 19F capsular locus, but multilocus sequence typing for several conserved genetic loci suggests that the strain sequenced belongs to a pneumococcal lineage that most often expresses a serotype 15 capsular polysaccharide. A total of 2,046 putative open reading frames (ORFs) longer than 100 amino acids were identified (average of 1,009 bp per ORF), including all described two-component systems and aminoacyl tRNA synthetases. Comparisons to other complete, or nearly complete, bacterial genomes were made and are presented in a graphical form for all the predicted proteins.
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| skos:exactMatch | |
| uniprot:name |
Microb. Drug Resist.
|
| uniprot:author |
Buell G.,
Caldara F.,
Dopazo J.,
Feger G.,
Friedli L.,
Gandin C.,
Garcia E.,
Garcia-Bustos J.F.,
Grand-Schenk E.,
Guerrier M.,
Herrero J.,
Humbert Y.,
Mendoza A.,
Peitsch M.,
Polissi A.,
de Francesco M.
|
| uniprot:date |
2001
|
| uniprot:pages |
99-125
|
| uniprot:title |
Annotated draft genomic sequence from a Streptococcus pneumoniae type 19F clinical isolate.
|
| uniprot:volume |
7
|
| dc-term:identifier |
doi:10.1089/10766290152044995
|