Nat. Cell Biol.

In genetic screens for new endocytosis genes in Caenorhabditis elegans we identified RME-1, a member of a conserved class of Eps15-homology (EH)-domain proteins. Here we show that RME-1 is associated with the periphery of endocytic organelles, which is consistent with a direct role in endocytic transport. Endocytic defects in rme-1 mutants indicate that the protein is likely to have a function in endocytic recycling. Evidence from studies of mammalian RME-1 also points to a function for RME-1 in recycling, specifically in the exit of membrane proteins from recycling endosomes. These studies show a conserved function in endocytic recycling for the RME-1 family of EH proteins.

Source:http://purl.uniprot.org/citations/11389442

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In genetic screens for new endocytosis genes in Caenorhabditis elegans we identified RME-1, a member of a conserved class of Eps15-homology (EH)-domain proteins. Here we show that RME-1 is associated with the periphery of endocytic organelles, which is consistent with a direct role in endocytic transport. Endocytic defects in rme-1 mutants indicate that the protein is likely to have a function in endocytic recycling. Evidence from studies of mammalian RME-1 also points to a function for RME-1 in recycling, specifically in the exit of membrane proteins from recycling endosomes. These studies show a conserved function in endocytic recycling for the RME-1 family of EH proteins.
skos:exactMatch
uniprot:name
Nat. Cell Biol.
uniprot:author
Grant B., Hall D.H., Hirsh D., Lin S.X., Paupard M.C., Zhang Y.
uniprot:date
2001
uniprot:pages
573-579
uniprot:title
Evidence that RME-1, a conserved C. elegans EH-domain protein, functions in endocytic recycling.
uniprot:volume
3
dc-term:identifier
doi:10.1038/35078549