In genetic screens for new endocytosis genes in Caenorhabditis elegans we identified RME-1, a member of a conserved class of Eps15-homology (EH)-domain proteins. Here we show that RME-1 is associated with the periphery of endocytic organelles, which is consistent with a direct role in endocytic transport. Endocytic defects in rme-1 mutants indicate that the protein is likely to have a function in endocytic recycling. Evidence from studies of mammalian RME-1 also points to a function for RME-1 in recycling, specifically in the exit of membrane proteins from recycling endosomes. These studies show a conserved function in endocytic recycling for the RME-1 family of EH proteins.
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In genetic screens for new endocytosis genes in Caenorhabditis elegans we identified RME-1, a member of a conserved class of Eps15-homology (EH)-domain proteins. Here we show that RME-1 is associated with the periphery of endocytic organelles, which is consistent with a direct role in endocytic transport. Endocytic defects in rme-1 mutants indicate that the protein is likely to have a function in endocytic recycling. Evidence from studies of mammalian RME-1 also points to a function for RME-1 in recycling, specifically in the exit of membrane proteins from recycling endosomes. These studies show a conserved function in endocytic recycling for the RME-1 family of EH proteins.
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skos:exactMatch | |
uniprot:name |
Nat. Cell Biol.
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uniprot:author |
Grant B.,
Hall D.H.,
Hirsh D.,
Lin S.X.,
Paupard M.C.,
Zhang Y.
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uniprot:date |
2001
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uniprot:pages |
573-579
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uniprot:title |
Evidence that RME-1, a conserved C. elegans EH-domain protein, functions in endocytic recycling.
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uniprot:volume |
3
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dc-term:identifier |
doi:10.1038/35078549
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