Sequences of fetuin cDNA and its deduced amino acid residues from the African green monkey cell line Vero were found to differ by 7.3% and 12.9%, respectively, from the corresponding human sequences. Most amino acid substitutions were clustered within a small segment of the third domain (D3). Calculations of nonsynonymous and synonymous nucleotide substitution rates suggest that this small segment was mutated under positive selection. cDNAs encoding alpha1-antitrypsin, beta-actin and the sequences of intron 4 of alpha1-antitrypsin gene in human liver and Vero cells were also investigated. The results substantiated the positive selection imposed on the D3 segment.
| Predicate | Object |
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| rdf:type | |
| rdfs:comment |
Sequences of fetuin cDNA and its deduced amino acid residues from the African green monkey cell line Vero were found to differ by 7.3% and 12.9%, respectively, from the corresponding human sequences. Most amino acid substitutions were clustered within a small segment of the third domain (D3). Calculations of nonsynonymous and synonymous nucleotide substitution rates suggest that this small segment was mutated under positive selection. cDNAs encoding alpha1-antitrypsin, beta-actin and the sequences of intron 4 of alpha1-antitrypsin gene in human liver and Vero cells were also investigated. The results substantiated the positive selection imposed on the D3 segment.
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| skos:exactMatch | |
| uniprot:name |
Biol. Chem.
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| uniprot:author |
Matsuura K.,
Sinohara H.,
Suzuki Y.,
Watanabe M.,
Yamamoto K.,
Yoshida K.
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| uniprot:date |
2000
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| uniprot:pages |
773-776
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| uniprot:title |
Molecular evolution in the hypervariable regions of fetuin: comparison between human and African green monkey fetuin.
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| uniprot:volume |
381
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| dc-term:identifier |
doi:10.1515/BC.2000.099
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