The S nucleotide sequences of five hepatitis B virus strains isolated from plasma samples of Tunisian patients with chronic hepatitis B were determined; the preS2 region of three of them were sequenced. According to the comparative analysis of S peptide sequences with the reported sequences in the database bank, the five hepatitis B strains were shown to be related to the D genotypic group, subtype ayw. The nature of residues at positions 125 and 127 allowed us to distinguish between each subtype of the D group and to class all five Tunisian sequences in the 'ayw2' subtype. Moreover, two of them (1366 and 523) contained a substitution of the invariant Cys69 by Arg and Cys221 by Phe, respectively. Potential structural modifications due to the Cys-Arg change are discussed.
| Predicate | Object |
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| rdf:type | |
| rdfs:comment |
The S nucleotide sequences of five hepatitis B virus strains isolated from plasma samples of Tunisian patients with chronic hepatitis B were determined; the preS2 region of three of them were sequenced. According to the comparative analysis of S peptide sequences with the reported sequences in the database bank, the five hepatitis B strains were shown to be related to the D genotypic group, subtype ayw. The nature of residues at positions 125 and 127 allowed us to distinguish between each subtype of the D group and to class all five Tunisian sequences in the 'ayw2' subtype. Moreover, two of them (1366 and 523) contained a substitution of the invariant Cys69 by Arg and Cys221 by Phe, respectively. Potential structural modifications due to the Cys-Arg change are discussed.
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| skos:exactMatch | |
| uniprot:name |
Microbes Infect.
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| uniprot:author |
Borchani-Chabchoub I.,
Gargouri A.,
Mokdad-Gargouri R.
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| uniprot:date |
2000
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| uniprot:pages |
607-612
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| uniprot:title |
Genotyping of Tunisian hepatitis B virus isolates based on the sequencing of preS2 and S regions.
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| uniprot:volume |
2
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| dc-term:identifier |
doi:10.1016/S1286-4579(00)00365-8
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