Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF alpha-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. In situ hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the PDGF alpha-receptor shows selective loss of mesenchymal cells adjacent to sites of expression of PDGF-C mRNA; this is not found in kidneys from animals lacking PDGF-A or both PDGF-A and PDGF-B, indicating that PDGF-C may have a unique function.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF alpha-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. In situ hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the PDGF alpha-receptor shows selective loss of mesenchymal cells adjacent to sites of expression of PDGF-C mRNA; this is not found in kidneys from animals lacking PDGF-A or both PDGF-A and PDGF-B, indicating that PDGF-C may have a unique function.
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| skos:exactMatch | |
| uniprot:name |
Nat. Cell Biol.
|
| uniprot:author |
Aase K.,
Abramsson A.,
Alitalo K.,
Backstrom G.,
Betsholtz C.,
Bostrom H.,
Eriksson U.,
Heldin C.H.,
Hellstrom M.,
Karlsson L.,
Li H.,
Li X.,
Ostman A.,
Ponten A.,
Soriano P.,
Uutela M.
|
| uniprot:date |
2000
|
| uniprot:pages |
302-309
|
| uniprot:title |
PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.
|
| uniprot:volume |
2
|
| dc-term:identifier |
doi:10.1038/35010579
|