Oligodendrocyte-specific protein (OSP/claudin-11) is a four transmembrane protein concentrated in central nervous system myelin. Recent evidence has emerged suggesting that OSP/claudin-11 is involved in membrane interactions at tight junctions and with the extracellular matrix. OSP/claudin-11 seems to modulate proliferation and migration of oligodendrocytes presumably through these interactions. Furthermore, evidence is presented implicating OSP/claudin-11 as an autoantigen in the development of autoimmune demyelinating disease.
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Oligodendrocyte-specific protein (OSP/claudin-11) is a four transmembrane protein concentrated in central nervous system myelin. Recent evidence has emerged suggesting that OSP/claudin-11 is involved in membrane interactions at tight junctions and with the extracellular matrix. OSP/claudin-11 seems to modulate proliferation and migration of oligodendrocytes presumably through these interactions. Furthermore, evidence is presented implicating OSP/claudin-11 as an autoantigen in the development of autoimmune demyelinating disease.
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| uniprot:name |
J. Neurosci. Res.
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| uniprot:author |
Bronstein J.M.,
Buznikov A.G.,
Stevens D.B.,
Tiwari-Woodruff S.
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| uniprot:date |
2000
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| uniprot:pages |
706-711
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| uniprot:title |
Involvement of OSP/claudin-11 in oligodendrocyte membrane interactions: role in biology and disease.
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| uniprot:volume |
59
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| dc-term:identifier |
doi:10.1002/(SICI)1097-4547(20000315)59:6<706::AID-JNR2>3.3.CO;2-4
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