FF118A05A061CEA5FA61AD86896C64702368AF01E523B38C6590F465E159C4E3140875AC1DEFEDD867AD887EB7F5FADC

Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression.

Source:http://purl.uniprot.org/SHA-384/FF118A05A061CEA5FA61AD86896C64702368AF01E523B38C6590F465E159C4E3140875AC1DEFEDD867AD887EB7F5FADC

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Predicate	Object
rdf:type	uniprot:Function_Annotation
rdfs:comment	Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression.