D5A282DB7271CC678A534D68BB48DF52ACC0C2A0E83122ED6585DAADAF72BE0F0969F0C7EB33DD7C815B050DD03D5D6E

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1.

Source:http://purl.uniprot.org/SHA-384/D5A282DB7271CC678A534D68BB48DF52ACC0C2A0E83122ED6585DAADAF72BE0F0969F0C7EB33DD7C815B050DD03D5D6E

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Predicate	Object
rdf:type	uniprot:Function_Annotation
rdfs:comment	Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1.