C21B3B056858C49F845AEABF8A3080F81D1BF59B12435411BA9ED4FCE6B755E0B6BEE905617A424C8A06B41B5BB6B10F

O-glycosylation at Thr-440 in the SET domain by OGT is essential for the histone methyltransferase and the coactivator activity toward RARA in granulopoiesis (By similarity). The absence of Thr-440 glycosylation in assays done in vitro may explain why PubMed:18952892 and PubMed:19264965 did not detected any histone methyltransferase activity for this protein.

Source:http://purl.uniprot.org/SHA-384/C21B3B056858C49F845AEABF8A3080F81D1BF59B12435411BA9ED4FCE6B755E0B6BEE905617A424C8A06B41B5BB6B10F

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Predicate	Object
rdf:type	uniprot:PTM_Annotation
rdfs:comment	O-glycosylation at Thr-440 in the SET domain by OGT is essential for the histone methyltransferase and the coactivator activity toward RARA in granulopoiesis (By similarity). The absence of Thr-440 glycosylation in assays done in vitro may explain why PubMed:18952892 and PubMed:19264965 did not detected any histone methyltransferase activity for this protein.