Rapid development. Cells are 4-fold more resistant to the antitumor agent cisplatin than are wild-type cells. Additionally it produces fruiting bodies with spore masses that cannot rise up the stalk during development. Mutant cells grow exponentially at the same rate as wild-type. Disruption of regA in a tagB null or in a tagC null background resulted in higher levels of sporulation. Disruption of regA in a dhka null background corrects the defect in stalk formation and suppresses the block to sporulation.
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Rapid development. Cells are 4-fold more resistant to the antitumor agent cisplatin than are wild-type cells. Additionally it produces fruiting bodies with spore masses that cannot rise up the stalk during development. Mutant cells grow exponentially at the same rate as wild-type. Disruption of regA in a tagB null or in a tagC null background resulted in higher levels of sporulation. Disruption of regA in a dhka null background corrects the defect in stalk formation and suppresses the block to sporulation.
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