Forms an icosahedral capsid with a 80-110 nm diameter together with the two other structural proteins hexon and penton. The fiber is divided into the tail, the shaft and the knob. The tails anchors the fiber to penton base capsomers, whereas the shaft, built from several repeated motifs, allows the knob to protude from the virion and interacts with host receptor at the cell surface to provide virion attachment to target cell. Adenovirus exploits its receptor for two important but distinct steps in its life cycle: attachment to host cells and escape across epithelial barriers to the environment. After virus has been endocytosed, fiber protein seems to modulate viral escape from host endosome/lysosome via organellar membrane lysis (By similarity).
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Forms an icosahedral capsid with a 80-110 nm diameter together with the two other structural proteins hexon and penton. The fiber is divided into the tail, the shaft and the knob. The tails anchors the fiber to penton base capsomers, whereas the shaft, built from several repeated motifs, allows the knob to protude from the virion and interacts with host receptor at the cell surface to provide virion attachment to target cell. Adenovirus exploits its receptor for two important but distinct steps in its life cycle: attachment to host cells and escape across epithelial barriers to the environment. After virus has been endocytosed, fiber protein seems to modulate viral escape from host endosome/lysosome via organellar membrane lysis (By similarity).
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