A682B3A92A73D729BA3EC213853C52568E4BFF5E69C13E57D9098BC630A38009034B06B3AD914DB12457840073DF93FC

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2 (By similarity).

Source:http://purl.uniprot.org/SHA-384/A682B3A92A73D729BA3EC213853C52568E4BFF5E69C13E57D9098BC630A38009034B06B3AD914DB12457840073DF93FC

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Predicate	Object
rdf:type	uniprot:Function_Annotation
rdfs:comment	Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2 (By similarity).