A5AB6D61CA2E1683E45D0E242CDAEA8ED8413353EE4D4FE0E1B05399D5C391D3B30BD44F6F5E3A9633277F2E7DC8FD2C

Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1 (By similarity).

Source:http://purl.uniprot.org/SHA-384/A5AB6D61CA2E1683E45D0E242CDAEA8ED8413353EE4D4FE0E1B05399D5C391D3B30BD44F6F5E3A9633277F2E7DC8FD2C

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Predicate	Object
rdf:type	uniprot:Function_Annotation
rdfs:comment	Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1 (By similarity).