A0BF3B92A7268042C9600C7736CD9BEBE817387FE8C5CC7511A317A62B2E1EE1BE11393F0A689425B99082F12FB29F71

The PAL motif is required for normal active site conformation (By similarity). The catalytic domains embedded in the membrane are in the opposite orientation to that of the presenilin protein family; therefore, it is predicted to cleave type II-oriented substrate peptides like the prototypic protease SPP (By similarity).

Source:http://purl.uniprot.org/SHA-384/A0BF3B92A7268042C9600C7736CD9BEBE817387FE8C5CC7511A317A62B2E1EE1BE11393F0A689425B99082F12FB29F71

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rdf:type	uniprot:Domain_Annotation
rdfs:comment	The PAL motif is required for normal active site conformation (By similarity). The catalytic domains embedded in the membrane are in the opposite orientation to that of the presenilin protein family; therefore, it is predicted to cleave type II-oriented substrate peptides like the prototypic protease SPP (By similarity).