9046F3EF96FEBED7F15ABCE37D5CFEF81E66FB1C3DF70BF94136A370542ECE9E4B3CC2E6235A73240CE0AA5492F55C51

The PAL motif is required for normal active site conformation (By similarity). The catalytic domains embedded in the membrane are in the opposite orientation to that of the presenilin protein family; therefore, it is predicted to cleave type II-oriented substrate peptides like the prototypic protease SPP.

Source:http://purl.uniprot.org/SHA-384/9046F3EF96FEBED7F15ABCE37D5CFEF81E66FB1C3DF70BF94136A370542ECE9E4B3CC2E6235A73240CE0AA5492F55C51

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rdf:type	uniprot:Domain_Annotation
rdfs:comment	The PAL motif is required for normal active site conformation (By similarity). The catalytic domains embedded in the membrane are in the opposite orientation to that of the presenilin protein family; therefore, it is predicted to cleave type II-oriented substrate peptides like the prototypic protease SPP.