8FEB3F8D1077C1647D38F85C0B74DD6F0EF5F4859D43ADDB592C4D8374880C86848CE3D48F1BF515AAED24B478F926AF

The mature envelope protein (Env) consists of a homotrimer of non-covalently associated gp120-gp41 heterodimers. The resulting complex protrudes from the virus surface as a spike. There seems to be as few as 10 spikes on the average virion. Surface protein gp120 interacts with human CD4, CCR5 and CXCR4, to form a P4HB/PDI-CD4-CXCR4-gp120 complex. Gp120 also interacts with the C-type lectins CD209/DC-SIGN and CLEC4M/DC-SIGNR (collectively referred to as DC-SIGN(R)). Gp120 and gp41 interact with GalCer (By similarity).

Source:http://purl.uniprot.org/SHA-384/8FEB3F8D1077C1647D38F85C0B74DD6F0EF5F4859D43ADDB592C4D8374880C86848CE3D48F1BF515AAED24B478F926AF

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Predicate	Object
rdf:type	uniprot:Subunit_Annotation
rdfs:comment	The mature envelope protein (Env) consists of a homotrimer of non-covalently associated gp120-gp41 heterodimers. The resulting complex protrudes from the virus surface as a spike. There seems to be as few as 10 spikes on the average virion. Surface protein gp120 interacts with human CD4, CCR5 and CXCR4, to form a P4HB/PDI-CD4-CXCR4-gp120 complex. Gp120 also interacts with the C-type lectins CD209/DC-SIGN and CLEC4M/DC-SIGNR (collectively referred to as DC-SIGN(R)). Gp120 and gp41 interact with GalCer (By similarity).