78A4740362F01E466BD4EE6FAC599C9F5D5A95BF7A6BD59C6C75C7A444F71B9ABDE4AA36DA2DD6BD40915684B822791B

Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity).

Source:http://purl.uniprot.org/SHA-384/78A4740362F01E466BD4EE6FAC599C9F5D5A95BF7A6BD59C6C75C7A444F71B9ABDE4AA36DA2DD6BD40915684B822791B

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Predicate	Object
rdf:type	uniprot:Function_Annotation
rdfs:comment	Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity).