547A0E618B7DACC1FC68536674782C09F4C8BA8F7E9489E1F662901324CD00770B6D977192943F44D56E4C7C4A8743C1

The papain-like proteinase 1 (PL1-PRO) and papain-like proteinase 2 (PL2-PRO) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF-3 (By similarity).

Source:http://purl.uniprot.org/SHA-384/547A0E618B7DACC1FC68536674782C09F4C8BA8F7E9489E1F662901324CD00770B6D977192943F44D56E4C7C4A8743C1

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Predicate	Object
rdf:type	uniprot:Function_Annotation
rdfs:comment	The papain-like proteinase 1 (PL1-PRO) and papain-like proteinase 2 (PL2-PRO) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF-3 (By similarity).