3C82D5816790006F53C8F378FC130DC649E0EB060C2133B17FDEDDC400F26BC22713581F3974915CA00F41C35D6B6603

Acetylation by EP300, CREBBP, GCN5L2/GCN5 and PCAF regulates the transactivation activity of Tat. EP300-mediated acetylation of Lys-50 promotes dissociation of Tat from the TAR RNA through the competitive binding to PCAF's bromodomain. In addition, the non-acetylated Tat's N-terminus can also interact with PCAF. PCAF-mediated acetylation of Lys-28 enhances Tat's binding to CCNT1. Lys-50 is deacetylated by SIRT1 (By similarity).

Source:http://purl.uniprot.org/SHA-384/3C82D5816790006F53C8F378FC130DC649E0EB060C2133B17FDEDDC400F26BC22713581F3974915CA00F41C35D6B6603

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Predicate	Object
rdf:type	uniprot:PTM_Annotation
rdfs:comment	Acetylation by EP300, CREBBP, GCN5L2/GCN5 and PCAF regulates the transactivation activity of Tat. EP300-mediated acetylation of Lys-50 promotes dissociation of Tat from the TAR RNA through the competitive binding to PCAF's bromodomain. In addition, the non-acetylated Tat's N-terminus can also interact with PCAF. PCAF-mediated acetylation of Lys-28 enhances Tat's binding to CCNT1. Lys-50 is deacetylated by SIRT1 (By similarity).