Between E7.25 and E8, expression detected in the extraembryonic mesoderm and contributes to amnion and chorion. Allantois expression persists until E10.5 and continues into the umbilical cord. Expression is found throughout heart development. At E7.5, detected in the cardiogenic mesoderm, at E8.0-8.5, found in the cardiac crescent and looping heart tube and from E9.5, found in the forming four-chambered heart. At all stages, expression is much stronger in the myocardium than in the endocardium and expression extends from the cardiogenic into the lateral plate mesoderm. From E10.5 on, weakly expressed in the periphery of the liver lobes, and in cells surrounding the aorta in the urogenital system. At E9.0, weakly expressed in the dorsal half of the optic vesicle. Later, expression spreads ventrally to enclose the entire neural retina at E11.5. At E9.0, expression is initiated in the hindbrain: first in the ventral region of rhombomere (r) 2 and 4, then in r7, r8 and in the cervical spinal cord. By E10.5, two ventral stripes of Tbx20 containing cells are continuous from r2 into the cervical spinal cord and expression is seen in two symmetrical patches of cell bodies in the mantle region of the ventral neural tube. At E11.5, expression follows the migration of motor neurons.
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Between E7.25 and E8, expression detected in the extraembryonic mesoderm and contributes to amnion and chorion. Allantois expression persists until E10.5 and continues into the umbilical cord. Expression is found throughout heart development. At E7.5, detected in the cardiogenic mesoderm, at E8.0-8.5, found in the cardiac crescent and looping heart tube and from E9.5, found in the forming four-chambered heart. At all stages, expression is much stronger in the myocardium than in the endocardium and expression extends from the cardiogenic into the lateral plate mesoderm. From E10.5 on, weakly expressed in the periphery of the liver lobes, and in cells surrounding the aorta in the urogenital system. At E9.0, weakly expressed in the dorsal half of the optic vesicle. Later, expression spreads ventrally to enclose the entire neural retina at E11.5. At E9.0, expression is initiated in the hindbrain: first in the ventral region of rhombomere (r) 2 and 4, then in r7, r8 and in the cervical spinal cord. By E10.5, two ventral stripes of Tbx20 containing cells are continuous from r2 into the cervical spinal cord and expression is seen in two symmetrical patches of cell bodies in the mantle region of the ventral neural tube. At E11.5, expression follows the migration of motor neurons.
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