Involved in the immune surveillance exerted by T and B lymphocytes. Functions as a natural cytotoxicity receptor to stimulate perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha.
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Involved in the immune surveillance exerted by T and B lymphocytes. Functions as a natural cytotoxicity receptor to stimulate perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha.
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