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This is a large and diverse family of putative metal chaperonesthat can be separated into up to 15 subgroups. In addition to known roles in cobalamin biosynthesis [1] and the activation of the Fe-type nitrile hydratase, this family is also known to be involved in the response to zinc limitation. The CobW subgroup involved in cobalamin synthesis represents only a small sub-fraction of the family [2].
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