| family:PF05450.10 | rdf:type | pfam:Family | lld:pfam |
| family:PF05450.10 | family:comment | Nicastrin and presenilin are two major components of thegamma-secretase complex, which executes the intramembrane proteolysis of type I integral membrane proteins such as the amyloid precursor protein (APP) and Notch. Nicastrin is synthesised in fibroblasts and neurons as an endoglycosidase-H-sensitive glycosylated precursor protein (immature nicastrin) and is then modified by complex glycosylation in the Golgi apparatus and by sialylation in the trans-Golgi network (mature nicastrin) [1]. A region featured in this family has a fold similar to human transferrin receptor (TfR, Swiss:P02786) and a bacterial aminopeptidase (Swiss:P80561). It is implicated in the pathogenesis of Alzheimer's disease [4]. | lld:pfam |
| family:PF05450.10 | family:id | Nicastrin | lld:pfam |
| family:PF05450.10 | family:description | Nicastrin | lld:pfam |
| family:PF05450.10 | family:authorList | Moxon SJ | lld:pfam |
| family:PF05450.10 | family:familyType | Family | lld:pfam |
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| family:PF05450.10 | family:pubmed | pubmed-article:11295540 | lld:pfam |
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